Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats
Poststroke depression is one of the major symptoms observed in the chronic stage of brain stroke such as cerebral ischemia.Its pathophysiological mechanisms, however, are not well understood.Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia model in this study, we first observed that aggravatio